Got into a chat recently with another EMT and once everything had shaken out, I realized that I wasn't actually sure whether nitro had been definitely associated with positive outcomes in well-powered research. The gold standard here might be aspirin -- having an MI, take ASA, the data shows more live tissue and better survival to discharge. Does this sort of evidence exist supporting similar use of nitrates? Or is it just "one of those things" that in reality is done mainly as palliative care?
I recognize the theoretical mechanism here, but that it makes sense doesn't mean that it works. And this is not an academic issue, since it is potentially important to deciding priorities when rendering care.
Anyone know of any studies?