Hey all, I'm writing a research paper on diastolic blood pressure in relation to fluid resuscitation, and I'm trying to nail down exactly what factors determine diastolic pressure. From what I've read, diastolic blood pressure is dependent directly on the Law of Laplace. In other words, Wall Tension = pressure x radius/ (2 x Wall Thickness). How could I relate this to the amount of volume circulating in the systemic vasculature?