Efficacy of entiemetics in unconscious CVA's

[BushyFromOz]

Round table duscission today, unconsicous CVA who is actively vomitng. With aised ICP and compression of the chemotactic trigger zone, would giving any 5HT3 agonists have any effect?

I tried searching pubmed etc with no luck, the second you have vomiting and CVA or stroke etc in a search it throws everything at you cause vomiting is in every stroke/CVA study as a side effect and limiting the search to the title gave me nothing.

[DwayneEMTP]

Round table duscission today, unconsicous CVA who is actively vomitng. With aised ICP and compression of the chemotactic trigger zone, would giving any 5HT3 agonists have any effect?

I tried searching pubmed etc with no luck, the second you have vomiting and CVA or stroke etc in a search it throws everything at you cause vomiting is in every stroke/CVA study as a side effect and limiting the search to the title gave me nothing.

Holy shit...awesome question...I don't even have a half assed guess...But am really looking forward to the discussion.

Dwayne

[chbare]

http://www.anesthesia-analgesia.org/content/91/2/358.full

Take care,

chbare.

[BushyFromOz]

Yeah i did find that one and a few more like it but i cant find anything that deals with acute CVA and its abnormal neurological function and loss of structural integrity. All the post op stuff i think would be relevent but not apples to apples methinks.

No basis in my statement, just throwing it out there.

Interesting, i did find a couple of cases of rasied ICP with metoclopromide admin

[celticcare]

How about Promethazine? I've used it twice as an anti emetic at work and surprisingly seemed to work. Helps with reduction of inflamation so could have a double effect?