Ketamine... PCA?

[HarryM]

Never used it in that way (Propofol or Midaz) - wouldn`t an already agitated patient be more open for the psychotropic aspects of the drug, I wonder?

Any experience or studies in comparison to other sedatives?

For sedation our preferred drug is Midaz but if you need to basically do a quick takedown for a very unstable patient who is a threat to others or themselves we can basically IM them with K using 2mg/kg up to 200mg max. Very effective. Only time I've seen it done patient became GCS 3 and maintained own airway well. No signs of respiratory depression. The issue we were having with midaz was that in patients that very highly combative due to amphetamines, you could hit with them with huge amounts of midaz with nil sedative effects but high risk of respiratory depression when you did finally get enough in to calm them down. One of the main reasons they brought in the K procedure for sedation.