TechMedic05 Posted May 11, 2006 Posted May 11, 2006 honestly, I have no clue. But for those who want to look it up, try: Here. Seems useful. Admittedly, I do need to review some more A P notes. heh.
chbare Posted May 15, 2006 Posted May 15, 2006 ERDoc, it is rather complex. As I remember INH inhibits several hepatic pathways that alter Vitamin B6 metabolism. B6 is metabolized to it's active form by the substances that are inhibited by INH. This leads to a reduction of a substance called pyridoxal-5-phosphate (P5P). P5P is needed for the production of an enzyme called l-glutamic acid decarboxylase. This enzyme is critical in the conversion of glutamic acid to GABA. GABA is decreased and glutamic acid increases. (glutamic acid is an excitatory neurotransmitter) The brain is over stimulated and prone to seizures. I will have to do a little research to go into more depth on the pathways and specific pathology. I do know of reports of people having seizures that take therapeutic levels, I ASSumed she may have overdosed. Thank you for calling me on that. Take care, chbare. Edit: PS, sorry I have not been around to post sooner. I just got back from an out of town trip. Take care, chbare.
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