D5W

[FL_Medic]

Are we using D5W for the sugar or so we aren't giving more sodium? Like in an Amidorone drip.

Quick and easy answer, please no copy/pastes..

[Just Plain Ruff]

well in order to get the scientific basis and studies Ace will cut and paste even if you ask him not to - (just kidding Ace)

[Ace844]

"FL_Medic,"

Are you asking if they use D5W in an amiodorance drip to 'ward off' Hyperchloremic acidosis and or hypernatremia? Just trying to understand your question more clearly.

ACE844

[AZCEP]

For Amiodarone specifically, because of it's actions as a sodium channel blocker, you wouldn't really want to use NS to mix it. The bigger issue is the container. Amiodarone will leach some of the material out of a standard IV bag/tubing.

None of the solutions are absolutely recommended over any other one. You would probably need to find out from your medical control why one and not the other.

[TechMedic05]

Are we using D5W for the sugar or so we aren't giving more sodium? Like in an Amidorone drip.

Quick and easy answer, please no copy/pastes..

There is no quick and easy answer. Anything should be somewhat supported.

[FL_Medic]

"FL_Medic,"

Are you asking if they use D5W in an amiodorance drip to 'ward off' Hyperchloremic acidosis and or hypernatremia? Just trying to understand your question more clearly.

ACE844

No, it was the sodium channel blocker thing, but we use it for other drugs, and I have never known why.

[Ace844]

No, it was the sodium channel blocker thing, but we use it for other drugs, and I have never known why.

Well I know for the long term part of why they mix it that way are for the reasons I mention above. Also considerations are 'compatibility' issues like the 'amiodarone'. Also, sometimes they use it with chemo drugs because they non-vessicant, and vessicant, so it is bad if they extravasate from a vessel.

Out Here,

ACE844

[Ridryder 911]

All the above + Technically, D_{5W in some text is an isotonic solution, especially the amount that would be given.}

_{R/r 911}

[vs-eh?]

I was under the impression that the impression that amiodarone was mixed in D5W because the dextrose is rapidly taken up by the cell and in turn acted as sort of a facilitated transport for the drug...

Also while D5W is initially an isotonic solution, it becomes hypotonic rapidly (again due to the fast uptake of glucose) in the form of sterile water. As I recall...

[chbare]

Vs-eh, that was my thinking along with Ridryder911. The solution is initially isotonic upon infusion. Then, as the dextrose is taken into the cell, the tonicity of the solution changes. Hypotonic water is left behind and the water wants to shift with it's gradient possibly promoting transport of the medication. Perhaps this is changed by the fact that a medication is mixed in the solution. I guess the quickest and easiest answer for using D5W as a delivery vehicle for some medications is because they will mix are there are no problems with compatibility.

Take care,

chbare.